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Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies

机译：在转基因动物中使用FcRn过表达的最新进展，以克服标准抗体技术的障碍，从而改善特异性抗体的产生

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This review illustrates the salutary effects of neonatal Fc receptor (FcRn) overexpression in significantly improving humoral immune responses in the generation of antibodies for immunotherapy and diagnostics. These include: (1) improved IgG protection; (2) augmented antigen-specific humoral immune response with larger numbers of antigen specific B cells, thus offering a wider spectrum of clones; (3) generation of antibodies against weakly immunogenic antigens; (4) significant improvements in the number and substantial developments in the diversity of hybridomas. FcRn transgenesis thus confers a number of practical benefits, including faster antibody production, higher antibody yields and improved generation of hybridomas for monoclonal antibody production. Notably, these efficiencies in polyclonal antibody production were also demonstrated in FcRn transgenic rabbits. Overall, FcRn transgenic animals yield more antibodies and provide a route to the generation of antibodies against antigens of low immunogenicity that are difficult to obtain using currently available methods.
机译：这项审查说明新生儿Fc受体（FcRn）过度表达在显着改善体液免疫反应的免疫疗法和诊断抗体产生中的有益作用。这些包括：（1）改善的IgG保护； （2）大量抗原特异性B细胞增强了抗原特异性体液免疫反应，从而提供了更广泛的克隆范围； （3）产生针对弱免疫原性抗原的抗体； （4）杂交瘤数量的显着改善和多样性的实质性发展。因此，FcRn转基因可带来许多实际的好处，包括更快的抗体生产，更高的抗体产量和改进的单克隆抗体生产杂交瘤的产生。值得注意的是，在FcRn转基因兔中也证明了多克隆抗体生产中的这些效率。总体而言，FcRn转基因动物产生更多的抗体，并提供了抗低免疫原性抗原的抗体生成途径，而使用现有方法很难获得。

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